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The Effect of Geraniol on Liver Regeneration After Hepatectomy in Rats .

Canbek, Mediha; Uyanoglu, Mustafa; Canbek, Selcuk; Ceyhan, Emre; Ozen, Ahmet; Durmus, Basak; Turgak, Ozge

Geraniol is a monoterpenoid alcohol that has a hepatoprotective effect. We investigated the regenerative effects of geraniol in rats after a 70% partial hepatectomy (PH). Using Wistar albino rats , nine groups were created: Group I was the control group, while the remaining groups received a single intraperitoneal dose of saline, Silymarin, or geraniol after PH. A 70% PH was performed on all groups except for groups II and III. Blood serum samples were obtained for alanine amino transferase (ALT) analysis. Then liver tissues were harvested for histological and real-time polymerase chain reaction (PCR) analyses. Tumor necrosis factor-α (TNFα) and interleukin 6 (IL6) gene expression were examined 24 and 48 h after PH. ALT levels were found to be statistically significantly increased in all PH-treated groups. TNFα and IL6 gene expression levels were elevated in geraniol-treated groups. Histological evaluation revealed a hepatoprotective effect for geraniol-treated groups. Our results suggest that geraniol plays a significant role during liver regeneration , which involves the elevated expression of TNFα and IL6 48 h after PH. Copyright© 2017, International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.

Three branches of phospholipase C signaling pathway promote hepatocyte growth in rat liver regeneration .

Xu, G G; Geng, Z; Zhou, X C; He, Y G; He, T T; Mei, J X; Yang, Y J; Liu, Y Q; Xu, C S

2015-05-29

In general, the phospholipase C (PLC) signaling pathway is involved in many physiological activities, including cell growth. However, little is known regarding how the PLC signaling pathway participates in regulating hepatocyte (HC) growth during liver regeneration (LR). To further explore the influence of the PLC signaling pathway on HCs at the cellular level, HCs of high purity and vitality were isolated using Percoll density-gradient centrifugation after partial hepatectomy. The genes of the PLC signaling pathway and target genes of transcription factors in the pathway were obtained by searching the pathways and transcription factor databases, and changes in gene expression of isolated HCs were examined using the Rat Genome 230 2.0 Microarray. The results suggested that various genes involved in the pathway (including 151 known genes and 39 homologous genes) and cell growth (including 262 known genes and 37 homologous genes) were associated with LR. Subsequently, the synergetic effect of these genes in LR was analyzed using a mathematical model (Et) according to their expression profiles. The results showed that the Et values of G protein-coupled receptor/PLC, integrin/PLC, and growth factor receptor/PLC branches of the PLC pathway were all significantly strengthened during the progression and termination phases of LR. The synergetic effect of target genes, in parallel with target gene-related cell growth, was also enhanced during whole rat LR, suggesting the potential positive effect of PLC on HC growth. The present data indicate that the PLC signaling pathway may promote HC growth through 3 mechanisms during rat LR after partial hepatectomy.

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andileibi
andileibi created the topic: Mit UCCNC verlorene Schritte errechnen
Mit WinPcNc kann man sich ja angeblich nach einem Job die anzahl der verlorenen Schritte berechnen lassen, geht das mit UCCNC auch?

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to join the conversation.

ubo replied the topic: Mit UCCNC verlorene Schritte errechnen
Nicht nur angeblich.
Gruß, Uwe WinPC-Nc V3, EstlCAM V11
andileibi replied the topic: Mit UCCNC verlorene Schritte errechnen
geht das mit UCCNC auch, ich hab da nichts gefunden?
Pirelli
Pirelli replied the topic: Mit UCCNC verlorene Schritte errechnen
Bei UCCNC habe ich von dieser Funktion noch nichts gehört oder gesehen. Wofür benötigt man die Funktion?
Viele Grüße Uli
Last Edit: 21 Jan 2018 16:14 by Pirelli .
andileibi replied the topic: Mit UCCNC verlorene Schritte errechnen
weils mich einfach interessiert ob die Maschine beim Fräsen Schritte verliert.

Pirelli wrote: Bei UCCNC habe ich von dieser Funktion noch nichts gehört oder gesehen. Wofür benötigt man die Funktion?

Pirelli replied the topic: Mit UCCNC verlorene Schritte errechnen
Ich frage mich da nur, wie die Steuerung der Steppie die verlorenen Schritte zählt. Über die Schrittmotoren gibt es doch keine Rückmeldung? Oder hab ich da was falsch verstanden?
Viele Grüße Uli
andileibi replied the topic: Mit UCCNC verlorene Schritte errechnen
Nach dem Job fährt die Steppi zum Referenzpunkt (errechnet) und dann Referenziert die Maschine, die Differenz zwischen den errechneten und tatsächlichen (über Endschalter) Referenzpunkt sind dann die verlorenen Schritte.
The following user(s) said Thank You: Pirelli
Burkhard
amplitude . track ( data )
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